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How long does nolotil take to work?

by Alivia Nyhan
Published: Last Updated on

Nolotil, Lasain, Novalgin are some of the brand names of the active compound metamizole or dipyrone. Although in some countries it is a drug used in daily practice for multiple health problems, in other countries its commercialization has been prohibited. Are you interested in knowing why? It can be very useful when deciding whether to use it or not, especially if you have an underlying disease.

If you want to know how long nolotil takes to work , what it is for, its doses, how often it should be taken, its side effects and the interaction with other medications, then continue reading this FastlyHealarticle.

What is nolotil for

Dipyrone or metamylzole (nolotil) is an active compound used for different problems:

  • Antipyretic: as a second option when the fever is very high and does not give way with common antipyretics, such as acetaminophen (paracetamol) and ibuprofen.
  • Painkiller: is used to relieve pain when other less toxic analgesics can not be used. It has an action comparable to aspirin (acetylsalicylic acid), but it produces less stomach damage than this and with a superior effect to paracetamol in moderate pain. It is used for pain of different types: postoperative, of tumor origin, post-traumatic, migraine attacks , among others.
  • Antispasmodic: it relaxes the smooth muscles of the liver, kidney and uterus, a quality that makes it useful to treat pain such as biliary colic, renal or menstrual colic.
  • Anti-inflammatory: low anti-inflammatory activity, compared to other anti-inflammatories (ibuprofen, aspirin, corticosteroids).

How long does nolotil take to work?

Dipyrone is very well absorbed orally, and takes about 30 minutes to start working, with nolotil reaching its peak of action between 30 and 120 minutes after taking it.

It continues in the body for up to 8 or 10 hours, gradually decreasing its action.

How many hours is nolotil taken?

The dose of nolotil changes depending on whether it is given to children or adults. It can be administered orally, injectable, or rectally. In this article, only reference is made to the oral route. It is important to say that the doses may vary according to medical criteria, here is the most common indication.

Nolotil should be taken every 6 hours maximum (4 times a day).


It is administered only in those older than 3 months at a rate of 12.5 mg / kg / dose, it can be administered up to 4 times a day. Then:

  • Children between 4 months and 4 years: 50-150 mg (2-6 drops), up to 4 times a day.
  • Children between 5 and 14 years: 250-375 mg (10-15 drops), up to 4 times a day.

Over 15 years old and adults

It is administered 500 mg (20 drops) or 1 tablet, up to 4 times a day.

The tablets should be swallowed whole, without chewing, aided by a little liquid.

Nolotil side effects

The side effects of nolotil are usually mild, such as hypotension, nausea, dry mouth, hot flashes, palpitations, or a skin reaction. There may be a reddish discoloration in the urine, which stops when it is stopped.

At high doses, the ability to drive may be affected, therefore, it is recommended that nolotil is not used if you have to use machinery, especially if it is combined with the ingestion of alcohol.

There are other infrequent but more serious adverse effects, which has led to its sale being suspended in countries such as Japan or the United States. These are:

  • Agranulocytosis: it is a serious problem in the blood, which causes the body’s defenses to be very low, causing serious infections, headache, fever, chills, sore throat. It improves when the medication is stopped, but it can be life-threatening if not treated in time.
  • Severe allergy (or anaphylaxis): due to an allergic predisposition of the person medicated with dipyrone.
  • Asthma: in people with asthma due to pain relievers.
  • Acute kidney failure: the kidneys stop working suddenly, decreasing the amount that the patient urinates as the main symptom.

This medication should not be used in the following cases:

  • Blood problems such as neutropenia or porphyria.
  • Infants
  • Pregnancy.
  • Lactation.

It should be used with caution and under medical supervision in case of:

  • Liver failure.
  • Renal insufficiency.
  • Use of other medications: aspirin, antineoplastics (methotrexate), immunosuppressants (cyclosporine), psychiatric medications (bupropion, chlorpromazine, lithium), oral anticoagulants, some antihypertensives and some diuretics.

For all the above, it is important that you do not self-medicate and that, if in doubt, you consult your trusted doctor.

This article is merely informative, at FastlyHeal .com we do not have the power to prescribe medical treatments or make any type of diagnosis. We invite you to see a doctor in the case of presenting any type of condition or discomfort.

If you want to read more articles similar to How long does nolotil take to take effect? , we recommend that you enter our category of Medication and medical tests .

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