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Flagenase 400: what it is for, dosage and side effects

by Alivia Nyhan
Published: Last Updated on

Flagenase 400 is one of the brand names for combining two drugs: metronidazole and diiodohydroxyquinoline. It usually comes in capsules and is indicated to treat various parasites.

These two drugs should be used with caution and under medical guidance, as they can have unwanted side effects that can be pretty complicated. In addition, this Medication is not indicated in pregnancy, lactation, or in those who suffer from certain diseases.

If you are interested in knowing more about what Flagenase 400 is for, the correct dose, how it is taken, the side effects and contraindications, read this FastlyHealarticle.

What is Flagenase 400 for?

Flagenase 400 is the brand name for a medication made up of metronidazole and diiodohydroxyquinoline.


Metronidazole is a powerful antiparasitic and antibiotic. It is very effective and, due to its mode of action, does not usually cause resistance. It is used alone or in combination with other medications to treat different types of infections, such as:

On the other hand, metronidazole is also used to keep the immune system depressed, so it is applied in inflammatory diseases such as rosacea.

Another use is to treat itching in patients who suffer from obstructions in the bile duct since it reduces the action of the bacteria in that area.


It is a medication used to treat amoebas, those microscopic beings that can sometimes cause parasitic infections known as amebiasis.

As it acts directly in the intestine and is practically not absorbed, it has no possibility of acting in other types of amoebiasis. Therefore, it is indicated almost exclusively to eradicate parasites on this site.

Among the microorganisms sensitive to this antiparasitic are:

  • Entamoeba histolytica.
  • Dientamoeba fragilis.
  • Blastocystis Man.

Both drugs have a relatively broad antiparasitic spectrum that treats parasitosis both inside and outside the intestines. In particular, it is used in amoebiasis and amoebic abscess cases in the liver.

Dose of Flagenase 400

Flagenase 400 comprises 400 mg of metronidazole and 200 mg of diiodohydroxyquinoline.

The dose will vary according to the weight, age, and pathologies suffered by the person who has indicated the treatment. That is why I recommend that you go to one or a medical professional to start the treatment and that you do not self-medicate.

As a general rule, it is indicated that children older than ten years and adults take one tablet every 8 hours, but this will also depend on the weight and the other characteristics that I have mentioned before.

On the other hand, in younger children, the dose is recommended to be 40 mg per day per kilogram of weight. This total dose is divided into three daily intakes.

How to take Flagenase 400

It is recommended to take the combination of metronidazole with diiodohydroxyquinoline every 8 hours and for ten days, although this indication may vary according to each particular case.

It is advisable to take this Medication after food intake, as it improves the action of diiodohydroxyquinoline.

You must bear in mind that both drugs exert a direct action both inside and outside the intestines, and if digestion is not proper, they may not have the effect you expect. I suggest that your diet be light and with easy-to-digest foods. Try to include whole grains, fresh and seasonal vegetables, fruits, legumes, nuts, seeds.

Likewise, it is essential to avoid processed foods, excess meat, dairy products, vegetable oils, among others.

What you should keep in mind is that during the treatment with Flagenase 400, you should not drink alcohol, and you should not do so until three days after having finished the capsules.

Flagenase 400 side effects

Flagenase 400 can cause various adverse effects or side reactions that are not desirable. That is why it should only be taken under medical prescription.

The metronidazole may cause:

  • Sickness.
  • Vomiting
  • Poor digestion
  • Bad taste in the mouth.
  • Bad breath.
  • Headaches.
  • Itch.
  • Urticaria.
  • Vision problems.
  • Discomfort in the light.
  • Urinary discomfort
  • Seizures

The diyodohidroxiquinoleína can also cause:

  • Dizziness
  • Headaches.
  • Indigestion.
  • Nausea and vomiting
  • Rash, hives.
  • Optical alterations.

If, after using this Medication, you notice the persistence of any of the symptoms mentioned above, you must consult the specialist who indicated it to you.

Contraindications of Flagenase 400

As we have mentioned, this drug can have significant adverse reactions, especially if you suffer from certain diseases. That is why it should not be used in case of :

  • Liver disease.
  • Eye nerve problems.
  • Allergy to any of the components.
  • Kidney problems
  • Bone marrow suppression.
  • Blood dyscrasias.
  • Neurological diseases.

It should not be used by pregnant women or women who are breastfeeding.

This article is merely informative. At FastlyHeal .com, we do not have the power to prescribe medical treatments or make any diagnosis. We invite you to see a doctor in the case of presenting any condition or discomfort.

If you want to read more articles similar to Flagenase 400: what it is for, dosage, and side effects, we recommend entering our Medication and medical tests category.

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