Trimebutine: what it is for, dosage and how it is taken

Trimebutine is used to treat and relieve symptoms of crampy pain or spasms , such as abdominal pain and cramps associated with irritable bowel syndrome .

It is also used in postoperative paralytic ileus (intestinal obstruction due to lack of movement of the intestinal muscles) to stimulate the resumption of intestinal transit after abdominal surgery.

Mechanism of action

Spasmolytics have different mechanisms of action. The intestinal muscles have different types of receptors that allow them to act. One of these types of receptors is the intestinal opiate receptors and at this level Trimebutine acts. Although they have several subtypes, Trimebutine does not have selectivity and acts on all of them, thus stimulating the motility of the intestine and thus regulating intestinal transit.

In addition, we have what is called the rectocolonic reflex, which is induced by a mediator that acts at that level called acetylcholine. This reflex is what produces the pain of colic.

Trimebutine would act on the Meissner and Auerbach nerve plexuses (found in the walls of the intestine) and would antagonize the effect of acetylcholine, thus avoiding pain.

This drug is known and distributed worldwide, so the presentations in which you can get it are very diverse. The most common presentations are:

• 100 mg tablets.
• 100, 200 and 300 mg tablets.
• 6 mg / ml suspension.
• 20 mg / ml oral solution.
• 5 mg / ml solution for injection.
• Granules and powder for suspension.

It can also be obtained in combination with Simethicone, which is used to treat symptoms caused by excess gas, such as bloating and pain.

It should be stored at room temperature, protected from light and moisture, always keeping it out of the reach of children.

The recommended dose of Trimebutine for adults is a maximum of 600 mg daily taken in 3 divided doses (200 mg, 3 times a day) before meals.

However, the dose will depend on the pathology to be treated and the specific conditions of each patient that the doctor must establish, so there is no “standard dose” that anyone could use.

Yes, although it is said to be a well-tolerated drug and its adverse effects are rare. Within these, we can mention:

• Allergic reactions, including rashes (hives, redness).
• Drowsiness or drowsiness
• Constipation or diarrhea
• Polyuria (urinating a lot).
• Abdominal distension.
• Stomach pain (epigastralgia).
• Dizziness
• Dry mouth.
• Sickness.
• Headaches.

The injection form can cause a drop in blood pressure if given too quickly.

Remember that various factors can affect the dose of a drug that a person needs, such as body weight, age, other conditions, and the use of other medications. If your doctor has prescribed a dose, do not change the way you take it without informing him beforehand.

In some countries its use is prohibited in children under 12 years of age. However, there are already studies on its use in children and many countries have suspension and / or drops, which must be administered under strict medical prescription and only in those over 2 years of age and under surveillance. Other contraindications are:

• It should not be consumed by people with hypersensitivity to Trimebutine.
• Nor should it be consumed by pregnant women as its effects on the fetus are unknown. To fulfill part of its effects, there are other medications that your doctor may recommend.
• Finally, it should not be consumed by women who breastfeed , since it is unknown if it passes into breast milk and what effect it could have on the baby.

This article is merely informative, at FastlyHeal .com we do not have the power to prescribe medical treatments or make any type of diagnosis. We invite you to see a doctor in the case of presenting any type of condition or discomfort.

If you want to read more articles similar to Trimebutine: what it is for, dosage and how it is taken , we recommend that you enter our Medication and medical tests category .