Vaginal mycoses are a frequent reason for consultation in gynecology due to the uncomfortable symptoms it generates. Some are irritation, discharge, and intense itching in the vagina and vulva. Fluconazole is an antifungal indicated in these conditions, one of them known as vaginal candidiasis, which is the most common. Knowing the time it takes for Fluconazole to take effect once it is started is one of the concerns that women with a fungal infection most often have. Therefore, in this FastlyHealarticle, we answer the question in detail, ” How long does Fluconazole take effect? “
Table of Contents
What is Fluconazole for
Fluconazole is a triazole compound with a broad spectrum of action. It is an antifungal medicine used to treat and prevent infections caused by both fungi and yeasts, such as vaginal or oral candidiasis.
This drug is taken orally with excellent results for the treatment of mycoses. It must be indicated by the doctor, and to acquire it, and you need a prescription.
It is indicated to treat infections caused by fungi such as:
- Candida spp.
- Cryptococcus neoformans.
- Microsporum spp.
- Blastomyces dermatitis.
- Histoplasma capsulatum.
Also, some of the infections that can be treated with this medicine are:
- Oral candidiasis: appears in the mouth and often occurs in children.
- Vaginal yeast infection.
- Candidiasis of the penis.
- Cryptococcosis: This lung infection is caused by breathing in soil contaminated by Cryptococcus neoformans.
- Onychomycosis: is the fungal infection of the nails.
- Tinea pedis: it is the most common fungal infection of the feet.
- Tinea cruris: It is known as the mycosis of the groin region.
- Blastomycosis: This is a fungal infection that is inhaled and enters the body through the lungs.
- Pityriasis Versicolor: fungal infection on the skin caused by the multiplication of the fungus Pityrosporum ovale that causes the appearance of white spots and skin lesions in some regions of the body.
- Coccidioidomycosis: is a lung infection caused by the Coccidiodes fungus when inhaled, which is found in the ground.
How long does it take for Fluconazole to work?
After starting treatment with Fluconazole, its effect will be evident 24 to 30 hours after the first dose is ingested. This is when the drug reaches an adequate concentration in the blood and tissues, and, in this way, its therapeutic effect begins.
This drug is absorbed quickly after being ingested. Its half-life lasts approximately 25 hours. 70% of the ingested dose is excreted unchanged.
In case of a yeast infection at the vaginal level, women should wait around three days to feel their symptoms improve. However, it would be best if you remembered that some women could become infected again within a month of receiving treatment.
A 150 mg dose of Fluconazole is safe and effective in treating yeast infections so that you will get relief from symptoms quickly.
How to take Fluconazole for yeast infection
Fluconazole should be taken in a dose of 150 mg once a day. Any form of candidiasis can be treated with this medicine. Depending on its severity, oral or intravenous treatment may be indicated.
If it is a fungal skin infection due to dermatophytes or candida, one tablet is indicated weekly for 2 to 6 weeks.
In cases of genital candidiasis, both in men and women, the recommended dose is 150 mg in a single dose. If it appears recurrently, the 150 mg dose should be repeated, and after three days, a single monthly amount should be given for 4 to 12 months.
In the case of oral candidiasis, the recommended dose will also be 150 mg daily for 7 to 14 days.
Can Fluconazole interact with other medications?
You should be aware that Fluconazole can interact with medications such as oral anticoagulants. In addition, it can enhance the effect of some medications, among which are:
- Digoxin
- Phenytoin
- Chlorpropamide
- Cyclosporine
- Midazolam
- Lovastatin
- Quinine
Interaction with these drugs can cause them to become toxic.
Rifampicin decreases serum levels of Fluconazole, unlike Hydrochlorothiazide, which increases them.
Fluconazole decreases the metabolism of estrogen. This causes its blood levels to be higher.
This compound does not affect the effectiveness of contraceptives when used for short periods.
This article is merely informative. At FastlyHeal .com, we do not have the power to prescribe medical treatments or make any diagnosis. We invite you to see a doctor if you present any condition or discomfort.
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
I am a Surgeon with a diploma in comprehensive ultrasound and surgical care residency, an area I am specializing in. During the exercise of my profession, I have realized the need for patients to know the diseases they suffer, and I can tell you that a large part of their complications is due to a lack of information. Being a health web writer allows me to transmit my experience, without borders, to all those readers eager for knowledge, educate them in the prevention of diseases and promote a healthy lifestyle.